Yabiki T, Namoika S
Am J Vet Res. 1976 May;37(5):535-40.
Studies were made of the immunoglobulin (Ig) in serums from umbilical cord of newborn pigs and maternal placenta. The neutralization test for porcine parvovirus and Japanese encephalitis virus was carried out with the serum of the sow and that of the umbilical cord of the newborn pig. Comparative studies of the serums from the dam and the umbilical cord were also done with gel filtration. Of 20 umbilical cord serum samples, IgG was seen in 5 samples (25%), IgA in 1 sample (5%), and IgM in 9 samples (45%). The amount of any 1 of the 3 classes of Ig in the serums was between 13.5 and 28.0 mg/dl. Among the samples examined, 1 had both IgG and IgA and 1 had IgG and IgM, but none had both IgA and IgM and none had 3 classes of immunoglobulins (i.e., IgG, IgA, and IgM). Only 7 samples (35%) did not have any class of Ig. The IgG disappeared from the blood of hysterectomy-produced colostrum-deprived pigs at 3 days of age, and IgM disappeared when pigs were 7 days of age. Neutralization antibodies of porcine parvovirus and Japanese encephalitis virus in maternal serum were not transferred to the fetus through the placenta. Results of immunohistologic surveys indicated that the sow's Ig were not transferred to the fetus through the placenta. Therefore, it is believed that the Ig in the porcine fetus might be synthesized in certain cells in the placental tissue, and the degree of production of the Ig in the placental tissues may differ in each case. The component, which seems to be Ig, was observed as the obscure band of the beta- to gamma-globulin area in serum of the umbilical cord. Comparison was made, with gel filtration, of maternal serum and serum from the umbilical cord of the newborn pig originating from the same sow. Seemingly, the IgG in the umbilical cord serum is mainly in the lower molecular weight fraction, whereas IgG in the sow's serum was distributed in the high to low molecular weight fractions.
对新生仔猪脐带血清和母体胎盘血清中的免疫球蛋白（Ig）进行了研究。用母猪血清和新生仔猪脐带血清对猪细小病毒和日本脑炎病毒进行了中和试验。还采用凝胶过滤法对母源血清和脐带血清进行了比较研究。在20份脐带血清样本中，5份（25%）检测到IgG，1份（5%）检测到IgA，9份（45%）检测到IgM。这三类Ig中任何一类在血清中的含量在13.5至28.0mg/dl之间。在所检测的样本中，1份同时含有IgG和IgA，1份同时含有IgG和IgM，但没有样本同时含有IgA和IgM，也没有样本同时含有三类免疫球蛋白（即IgG、IgA和IgM）。只有7份样本（35%）未检测到任何一类Ig。子宫切除产生的初乳缺乏仔猪在3日龄时血液中的IgG消失，IgM在仔猪7日龄时消失。母体血清中猪细小病毒和日本脑炎病毒的中和抗体未通过胎盘转移给胎儿。免疫组织学调查结果表明，母猪的Ig未通过胎盘转移给胎儿。因此，据信猪胎儿体内的Ig可能是在胎盘组织中的某些细胞中合成的，并且胎盘组织中Ig的产生程度在每种情况下可能有所不同。在脐带血清中，似乎是Ig的成分在β-γ球蛋白区域呈现为模糊条带。采用凝胶过滤法对同一母猪的母源血清和新生仔猪脐带血清进行了比较。似乎脐带血清中的IgG主要存在于低分子量部分，而母猪血清中的IgG分布在高分子量至高-低分子量部分。
