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从基因组学、蛋白质组学到细胞组学,或从细胞计数术到细胞组学

[From genomics, proteomics to cytomics, or from cytometry to cytomics].

作者信息

Gong Jian-Ping

机构信息

Cancer Research Institute, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan, Hubei, PR China.

出版信息

Ai Zheng. 2003 May;22(5):449-51.


DOI:
PMID:12753700
Abstract

Cytomics, an ad hoc term, represents a new field which connects cyto- with -omics. The cyto- arises from analytical cytology or cytometry, which has developed for more than three decades and includes a serial of quantitative technology which can separate the heterogenetic cell populations into different cytomes by molecular probes. The -omics comes from proteomics which is determined by genomics. Therefore, cytomics is to separate the cytomes by cytometry technology and identify their proteomes controlled by genome or special genes. Cytomics project consists of two parts of technology, one is separation of cytomes and another is post-sorting analysis. Development of cytomics related technology would help us to understand molecular basis of different cytomes and the transition between them, to gradually grasp the details of genomics, and to know of how to apply them for clinical work. Thus, a new horizon will appear.

摘要

细胞组学,一个特定术语,代表了一个将“细胞”与“组学”联系起来的新领域。“细胞”源自分析细胞学或细胞计数法,其发展已有三十多年,包括一系列定量技术,这些技术可通过分子探针将异质细胞群体分离成不同的细胞组。“组学”来自由基因组学决定的蛋白质组学。因此,细胞组学就是通过细胞计数技术分离细胞组,并鉴定由基因组或特定基因控制的蛋白质组。细胞组学项目由两部分技术组成,一部分是细胞组的分离,另一部分是分选后分析。细胞组学相关技术的发展将有助于我们理解不同细胞组的分子基础以及它们之间的转变,逐步掌握基因组学的细节,并了解如何将其应用于临床工作。这样,一个新的视野将会出现。

相似文献

[1]
[From genomics, proteomics to cytomics, or from cytometry to cytomics].

Ai Zheng. 2003-5

[2]
Cytomics: A multiparametric, dynamic approach to cell research.

Toxicol In Vitro. 2007-3

[3]
Microscopy-based multicolor tissue cytometry at the single-cell level.

Cytometry A. 2004-6

[4]
New technologies for the human cytome project.

J Biol Regul Homeost Agents. 2004

[5]
Cytomics in characterizing toponomes: towards the biological code of the cell.

Cytometry A. 2006-4

[6]
Clinical flow cytometry, a hypothesis-driven discipline of modern cytomics.

Cytometry A. 2004-3

[7]
[Development of antituberculous drugs: current status and future prospects].

Kekkaku. 2006-12

[8]
Slide-based cytometry for cytomics--a minireview.

Cytometry A. 2006-7

[9]
Integrating cytomics and proteomics.

Mol Cell Proteomics. 2006-1

[10]
Cytomics.

Curr Drug Metab. 2008-3

引用本文的文献

[1]
From Human Cytogenetics to Human Chromosomics.

Int J Mol Sci. 2019-2-14

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