L-精氨酸甲酯（L-NAME）静脉输注对健康志愿者中心和外周血流动力学的影响。

Central and peripheral haemodynamic effects of L-NAME infusion in healthy volunteers.

作者信息

Morgan D R, Silke B, Dixon L J, Allen P B, Hanratty C G, McVeigh G E

机构信息

Therapeutics and Pharmacology, The Whitla Division of Medicine, The Queen's University of Belfast, Whitla Medical Building, 97 Lisburn Road, BT9 7BL Belfast, Northern Ireland.

出版信息

Eur J Clin Pharmacol. 2003 Jul;59(3):195-9. doi: 10.1007/s00228-003-0601-7. Epub 2003 May 17.

DOI:10.1007/s00228-003-0601-7

PMID:12756513

Abstract

AIMS

To evaluate the effects of the intravenous administration of the nitric oxide synthesis inhibitor N(g)nitro-L-arginine methyl ester (L-NAME) in healthy volunteers.

METHODS

L-NAME (0.25, 0.5 and 0.75 mg/kg over 8 min) was infused in 13 healthy male volunteers. Finally, subjects were infused with either L- or D-arginine.

RESULTS

L-NAME resulted in dose-dependent falls in heart rate 60 bpm (55-64 bpm) to 49 bpm (46-52 bpm) (P<0.01) and increased mean arterial pressure 77.0 mmHg (73.2-80.8 mmHg) to 90.0 mmHg (87.1-92.8 mmHg) (P<0.01). The cardiac output was significantly reduced after each L-NAME infusion, and systemic vascular resistance increased linearly over the dosage range. Cardiac stroke volume was significantly reduced only following 0.75 mg/kg/min L-NAME: from 100 ml (91.3-108.7 ml) to 83 ml (74.7-91.4 ml); P<0.01. Forearm blood flow was unchanged at any dosage. L-arginine but not D-arginine infusion reversed the haemodynamic effects of L-NAME.

CONCLUSIONS

Contrasting with the profound dose-dependent effects of L-NAME had significant effects on central haemodynamics but no discernible effects on peripheral blood flow.

摘要

目的

评估静脉注射一氧化氮合成抑制剂N（G）-硝基-L-精氨酸甲酯（L-NAME）对健康志愿者的影响。

方法

对13名健康男性志愿者输注L-NAME（8分钟内0.25、0.5和0.75mg/kg）。最后，给受试者输注L-或D-精氨酸。

结果

L-NAME导致心率呈剂量依赖性下降，从60次/分钟（55-64次/分钟）降至49次/分钟（46-52次/分钟）（P<0.01），平均动脉压从77.0mmHg（73.2-80.8mmHg）升高至90.0mmHg（87.1-92.8mmHg）（P<0.01）。每次输注L-NAME后心输出量均显著降低，全身血管阻力在剂量范围内呈线性增加。仅在输注0.75mg/kg/min L-NAME后心搏量显著降低：从100ml（91.3-108.7ml）降至83ml（74.7-91.4ml）；P<0.01。任何剂量下前臂血流量均无变化。输注L-精氨酸而非D-精氨酸可逆转L-NAME的血流动力学效应。