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华法林长期治疗的强度受季节变化影响。

Intensity of long-term treatment with warfarin is influenced by seasonal variations.

作者信息

Salobir Barbara, Sabovic Miso, Peternel Polona

机构信息

Department of Vascular Diseases, University Medical Centre, Ljubljana, Slovenia.

出版信息

Pathophysiol Haemost Thromb. 2002 Jul-Aug;32(4):151-4. doi: 10.1159/000070419.

Abstract

In a prospective study, which lasted 1 year and was performed on a large cohort of 800 patients treated at an outpatient anticoagulant clinic, we investigated possible seasonal variations in the intensity of the effect of warfarin treatment. For every season--winter, spring, summer and autumn--the mean prothrombin time reported as an international normalised ratio (INR) and the percentages of INR below 2.0 and above 4.0 were calculated. Significant seasonal variations in mean INR measurements were found, with the lowest values in summer and the highest values in autumn (F = 14.2, p < 0.0001). In addition, a trend toward a higher percentage of INR below 2.0 in summer and above 4.0 in autumn was observed. No significant differences were found between older (>65 years) and younger (<65 years) patients, although there was a trend toward more pronounced variations in younger patients. Consideration of seasonal variations might result in more accurate and safe guidance of warfarin treatment.

摘要

在一项为期1年的前瞻性研究中,我们对一家门诊抗凝诊所治疗的800名患者的大型队列进行了研究,调查了华法林治疗效果强度可能存在的季节性变化。对于每个季节——冬季、春季、夏季和秋季——计算以国际标准化比值(INR)报告的平均凝血酶原时间以及INR低于2.0和高于4.0的百分比。发现平均INR测量值存在显著的季节性变化,夏季最低,秋季最高(F = 14.2,p < 0.0001)。此外,观察到夏季INR低于2.0和秋季高于4.0的百分比有升高趋势。在老年(>65岁)和年轻(<65岁)患者之间未发现显著差异,尽管年轻患者的变化趋势更明显。考虑季节性变化可能会对华法林治疗进行更准确、安全的指导。

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