肌钙蛋白T和肌红蛋白水平在急性心肌梗死中的诊断价值：一项针对土耳其患者的研究。

The diagnostic value of troponin T and myoglobin levels in acute myocardial infarction: a study in Turkish patients.

作者信息

Vatansever S, Akkaya V, Erk O, Oztürk S, Karan M A, Salmayenli N, Taşçioğlu C, Güler K

机构信息

Department of Internal Medicine, Division of Emergency Medicine, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.

出版信息

J Int Med Res. 2003 Mar-Apr;31(2):76-83. doi: 10.1177/147323000303100203.

DOI:10.1177/147323000303100203

PMID:12760310

Abstract

This study compares the diagnostic value of troponin T (TnT) and myoglobin with creatinine kinase (CK) for myocardial infarction (MI) in a tertiary care centre in a developing nation. The study group comprised 33 acute myocardial infarction patients and 27 healthy controls. Receiver operating characteristic curves for TnT, myoglobin and CK were drawn and areas under the curve calculated. At admission, myoglobin levels had greater diagnostic sensitivity than TnT or CK levels. After 2 h, myoglobin and TnT had equal sensitivity and specificity, whereas CK still had lower sensitivity than myoglobin and TnT. After 4 h there was no difference between the tests. It was concluded that myoglobin levels on admission and TnT at 2 h had the greatest diagnostic rate, whereas all the tests were similar after 4 h for MI.

摘要

本研究在一个发展中国家的三级医疗中心比较了肌钙蛋白T（TnT）、肌红蛋白与肌酸激酶（CK）对心肌梗死（MI）的诊断价值。研究组包括33例急性心肌梗死患者和27例健康对照者。绘制了TnT、肌红蛋白和CK的受试者工作特征曲线，并计算曲线下面积。入院时，肌红蛋白水平的诊断敏感性高于TnT或CK水平。2小时后，肌红蛋白和TnT的敏感性和特异性相等，而CK的敏感性仍低于肌红蛋白和TnT。4小时后，各项检测之间无差异。得出的结论是，入院时的肌红蛋白水平和2小时时的TnT诊断率最高，而4小时后所有检测对心肌梗死的诊断结果相似。