超声引导下经皮乙醇注射治疗甲状腺囊肿与实性甲状腺结节的疗效比较
Efficacy of sonographically guided percutaneous ethanol injection for treatment of thyroid cysts versus solid thyroid nodules.
作者信息
Kim Jin Hyoung, Lee Ho Kyu, Lee Jung Hyun, Ahn Il Min, Choi Choong Gon
机构信息
Department of Diagnostic Radiology, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Poongnap-dong, Songpa-gu, Seoul 138-736, Korea.
出版信息
AJR Am J Roentgenol. 2003 Jun;180(6):1723-6. doi: 10.2214/ajr.180.6.1801723.
OBJECTIVE
Sonographically guided percutaneous ethanol injection has been recently proposed as a treatment for nonfunctioning benign thyroid nodules such as cysts or solid nodules. The objective of this study was to compare the efficacy of ethanol injection in thyroid cysts and solid nodules.
SUBJECTS AND METHODS
We studied 20 patients with simple or complex thyroid cysts and 22 patients with solid thyroid nodules. All lesions were confirmed by fine-needle aspiration biopsy to be benign. The mean volume of the instilled absolute ethanol (99.9%) was 62.2% of the whole tumor volume for solid nodules and 63.4% of the cystic volume for cysts. Follow-up sonography was performed 1-6 months (mean, 4.4 months for cysts and 4.6 months for solid nodules) after the procedure.
RESULTS
The mean volume reduction rate for cysts (65%) was greater than that for solid nodules (38.3%) (p < 0.01, Student's t test). The volume of the instilled ethanol correlated significantly with the volume reduction rate of cysts but not with that of solid nodules (p < 0.01, Student's t test).
CONCLUSION
Sonographically guided percutaneous ethanol injection is more effective for thyroid cysts than for solid thyroid nodules.
目的
最近有人提出超声引导下经皮乙醇注射可用于治疗无功能的良性甲状腺结节，如囊肿或实性结节。本研究的目的是比较乙醇注射治疗甲状腺囊肿和实性结节的疗效。
对象与方法
我们研究了20例单纯性或复杂性甲状腺囊肿患者和22例甲状腺实性结节患者。所有病变均经细针穿刺活检证实为良性。对于实性结节，注入的无水乙醇（99.9%）平均体积为整个肿瘤体积的62.2%；对于囊肿，注入的无水乙醇平均体积为囊肿体积的63.4%。术后1 - 6个月（囊肿平均4.4个月，实性结节平均4.6个月）进行超声随访。
结果
囊肿的平均体积缩小率（65%）大于实性结节（38.3%）（p < 0.01，Student's t检验）。注入乙醇的体积与囊肿的体积缩小率显著相关，但与实性结节的体积缩小率无关（p < 0.01，Student's t检验）。
结论
超声引导下经皮乙醇注射治疗甲状腺囊肿比治疗甲状腺实性结节更有效。
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