Gan Seng Khee, Kriketos Adamandia D, Ellis Bronwyn A, Thompson Campbell H, Kraegen Edward W, Chisholm Donald J
Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Sydney, NSW, Australia.
Diabetes Care. 2003 Jun;26(6):1706-13. doi: 10.2337/diacare.26.6.1706.
To examine the effect of moderate intensity physical activity on the interactions between central abdominal adiposity, myocyte lipid content, and insulin action in overweight and obese, sedentary men.
Myocyte lipid (biochemical triglyceride and long-chain acyl CoA [LCAC] from vastus lateralis biopsy and soleus and tibialis anterior intramyocellular lipid by (1)H-magnetic resonance spectroscopy), regional body and abdominal fat (dual-energy X-ray absorptiometry and magnetic resonance imaging), serum lipids, insulin action (hyperinsulinemic-euglycemic clamp), and substrate oxidation were measured in 18 nondiabetic, sedentary, and overweight to obese men (aged 37.4 +/- 1.3 years and BMI 30.9 +/- 0.7 kg/m(2), range 26.4-37.6) at baseline, after the first two to four bouts of aerobic exercise (55-70% of VO(2max) for 40 min/session), and at completion of 4.1 +/- 0.2 exercise sessions/week for 9.7 +/- 0.5 weeks (postexercise measurements performed 24-36 h after the last exercise bout).
Mean whole body insulin-stimulated glucose uptake and basal fat oxidation rate increased 16 and 41%, respectively, after two to four bouts of exercise, without further increase at program end. Mean aerobic capacity increased 11%, and central abdominal fat decreased 5% at program end, but myocyte lipid levels were not significantly changed. Posttraining increases in insulin-stimulated glucose uptake were predicted by increase in aerobic capacity (r = 0.726, P = 0.001) and magnitude of reduction in visceral fat (r = -0.544, P = 0.02) and not by changes in myocyte lipid or LCAC levels.
These results suggest that in overweight and obese sedentary men, increase in insulin sensitivity with moderate intensity exercise is predicted by improvement in aerobic capacity and reduction in visceral fat but is independent of myocyte triglyceride or LCAC levels.
研究中等强度体育活动对超重及肥胖、久坐不动男性的腹部中央肥胖、心肌细胞脂质含量和胰岛素作用之间相互关系的影响。
对18名非糖尿病、久坐不动、超重至肥胖男性（年龄37.4±1.3岁，BMI 30.9±0.7kg/m²，范围26.4 - 37.6）进行如下指标测量：通过外侧股活检获取的心肌细胞脂质（生化甘油三酯和长链酰基辅酶A [LCAC]）以及通过（1）H磁共振波谱法测量的比目鱼肌和胫骨前肌细胞内脂质；身体局部和腹部脂肪（双能X线吸收法和磁共振成像）；血脂；胰岛素作用（高胰岛素正常血糖钳夹法）；底物氧化。在基线时、头两至四次有氧运动（每次40分钟，运动强度为VO₂max的55 - 70%）后以及完成每周4.1±0.2次运动、持续9.7±0.5周后（末次运动后24 - 36小时进行运动后测量）分别进行上述测量。
经过两至四次运动后，平均全身胰岛素刺激的葡萄糖摄取量和基础脂肪氧化率分别增加了16%和41%，在运动计划结束时未进一步增加。运动计划结束时，平均有氧能力增加了11%，腹部中央脂肪减少了5%，但心肌细胞脂质水平无显著变化。训练后胰岛素刺激的葡萄糖摄取量的增加可通过有氧能力的增加（r = 0.726，P = 0.001）和内脏脂肪减少的幅度（r = -0.544，P = 0.02）来预测，而非通过心肌细胞脂质或LCAC水平的变化来预测。
这些结果表明，在超重及肥胖、久坐不动的男性中，中等强度运动导致的胰岛素敏感性增加可通过有氧能力的改善和内脏脂肪的减少来预测，但与心肌细胞甘油三酯或LCAC水平无关。
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