Mungan N, Yuksel B, Bakman M, Topaloglu A K, Ozer G
Division of Pediatric Endocrinology and Metabolism, Cukurova University, Faculty of Medicine, Adana, Turkey.
Indian Pediatr. 2003 May;40(5):410-4.
We measured urinary albumin excretion rate (AER) and N-acetyl-beta-D-glucosaminidase (NAG) activity in relation to disease duration, acetylated hemoglobin (HbA1c), hypertension and puberty in 44 children and adolescents with type 1 diabetes mellitus. AER and Urinary NAG activity were significantly higher in the patients compared to controls (AER 19.4 +/-; 35.8 vs 4.7 +/- 4.4, NAG activity 5.6 +/- 0.6U vs. 1.6 +/- 0.2U). Microalbuminuria was present in seven patients (15.9%), all of whom were pubertal. There was no correlation between AER and urinary NAG activity. There was a significant direct correlation between AER and disease duration (P <0.05), HbA1c (P < 0.05), diastolic blood pressure (P <0.05) and puberty (P <0.05). None of the microalbuminuria related variables was significantly correlated with urinary NAG activity. Puberty was an independent factor for elevated urinary NAG activity. This study shows that urinary NAG is elevated in children and adolescents with type 1 diabetes mellitus, but is not associated with AER related factors except for puberty. Urinary NAG activity does not appear to be a useful marker for early detection of diabetic nephropathy in children and adolescents with type 1 diabetes mellitus.
我们测定了44例1型糖尿病儿童和青少年的尿白蛋白排泄率（AER）和N-乙酰-β-D-氨基葡萄糖苷酶（NAG）活性，并分析其与病程、糖化血红蛋白（HbA1c）、高血压和青春期的关系。与对照组相比，患者的AER和尿NAG活性显著更高（AER：19.4±35.8 vs 4.7±4.4，NAG活性：5.6±0.6U vs 1.6±0.2U）。7例患者（15.9%）存在微量白蛋白尿，他们均处于青春期。AER与尿NAG活性之间无相关性。AER与病程（P<0.05）、HbA1c（P<0.05）、舒张压（P<0.05）和青春期（P<0.05）之间存在显著正相关。与微量白蛋白尿相关的变量均与尿NAG活性无显著相关性。青春期是尿NAG活性升高的独立因素。本研究表明，1型糖尿病儿童和青少年的尿NAG升高，但除青春期外，与AER相关因素无关。尿NAG活性似乎不是1型糖尿病儿童和青少年早期糖尿病肾病检测的有用标志物。
