Morozov Sergey Yu, Solovyev Andrey G
A. N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow 119899, Russia.
J Gen Virol. 2003 Jun;84(Pt 6):1351-1366. doi: 10.1099/vir.0.18922-0.
Many plant virus genera encode a 'triple gene block' (TGB), a specialized evolutionarily conserved gene module involved in the cell-to-cell and long-distance movement of viruses. The TGB-based transport system exploits the co-ordinated action of three polypeptides to deliver viral genomes to plasmodesmata and to accomplish virus entry into neighbouring cells. Although data obtained on both the TGB and well-studied single protein transport systems clearly demonstrate that plant viruses employ host cell pathways for intra- and intercellular trafficking of genomic nucleic acids and proteins, there is no integral picture of the details of molecular events during TGB-mediated virus movement. Undoubtedly, understanding the molecular basis of the concerted action of TGB-encoded proteins in transporting viral genomes from cell to cell should provide new insights into the general principles of movement protein function. This review describes the structure, phylogeny and expression of TGB proteins, their roles in virus cell-to-cell movement and potential influence on host antiviral defences.
许多植物病毒属编码一个“三基因块”（TGB），这是一个专门的、进化上保守的基因模块，参与病毒的细胞间和长距离移动。基于TGB的运输系统利用三种多肽的协同作用，将病毒基因组传递到胞间连丝，并使病毒进入邻近细胞。尽管关于TGB和研究充分的单蛋白运输系统所获得的数据清楚地表明，植物病毒利用宿主细胞途径进行基因组核酸和蛋白质的细胞内和细胞间运输，但对于TGB介导的病毒移动过程中分子事件的细节尚无完整的描述。毫无疑问，了解TGB编码蛋白在将病毒基因组从一个细胞运输到另一个细胞时协同作用的分子基础，将为移动蛋白功能的一般原理提供新的见解。本综述描述了TGB蛋白的结构、系统发育和表达，它们在病毒细胞间移动中的作用以及对宿主抗病毒防御的潜在影响。
