以莽草酸途径酶为靶点进行合理药物设计的经验。
Experiences with the shikimate-pathway enzymes as targets for rational drug design.
作者信息
Coggins J R, Abell C, Evans L B, Frederickson M, Robinson D A, Roszak A W, Lapthorn A P
机构信息
Division of Biochemistry & Molecular Biology, Institute of Biomedical & Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
出版信息
Biochem Soc Trans. 2003 Jun;31(Pt 3):548-52. doi: 10.1042/bst0310548.
The background and current context of work on the shikimate-pathway enzymes as potential targets for anti-bacterial, anti-fungal and anti-parasitic drugs is reviewed. Recent work on the third enzyme of the pathway, dehydroquinase, which occurs in two structurally and mechanistically distinct forms, is used to illustrate the present state of studies into rational drug design.
本文综述了莽草酸途径中的酶作为抗菌、抗真菌和抗寄生虫药物潜在靶点的研究背景和当前现状。该途径的第三种酶脱氢奎尼酸酶存在两种结构和作用机制不同的形式，本文以对其的最新研究为例来说明合理药物设计的研究现状。
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