Kuchroo Vijay K, Umetsu Dale T, DeKruyff Rosemarie H, Freeman Gordon J
Center for Neurologic Diseases, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.
Nat Rev Immunol. 2003 Jun;3(6):454-62. doi: 10.1038/nri1111.
The search for cell-surface markers that can distinguish T helper 1 (T(H)1) cells from T(H)2 cells has led to the identification of a new gene family, encoding the T-cell immunoglobulin mucin (TIM) proteins, some of which are differentially expressed by T(H)1 and T(H)2 cells. The role of the TIM-family proteins in immune regulation is just beginning to emerge. Here, we describe the various TIM-family members in mice and humans, and discuss the genetic and functional evidence for their role in regulating autoimmune and allergic diseases.
寻找能够区分辅助性T细胞1（T(H)1）和辅助性T细胞2（T(H)2）的细胞表面标志物，已促使人们鉴定出一个新的基因家族，该家族编码T细胞免疫球蛋白黏蛋白（TIM）蛋白，其中一些蛋白在T(H)1细胞和T(H)2细胞中呈差异表达。TIM家族蛋白在免疫调节中的作用才刚刚开始显现。在此，我们描述了小鼠和人类中的各种TIM家族成员，并讨论了它们在调节自身免疫性疾病和过敏性疾病中作用的遗传学和功能证据。
