Siddiqui I A, Jaleel A, Rahman M A
Department of Biochemistry, Ziauddin Medical University, Karachi.
J Pak Med Assoc. 2003 Apr;53(4):131-3.
To compare improvement in hemoglobin, mean corpuscular volume, mean corpuscular hemoglobin and ferritin levels in children aged 5-10 years and women of reproductive age (15-45) supplemented with daily oral and once weekly with single and double dose of ferrous sulphate.
Twenty children received 200 mg ferrous sulfate daily and 20 received the same dose once weekly for two months. Ten women received 300 mg ferrous sulfate daily, 10 received the same dose once weekly while 10 received 600 mg of ferrous sulfate once weekly for one month.
All parameters improved significantly in children who received 200 mg ferrous sulfate daily and weekly. Similarly, the parameters improved significantly in women who received 300 mg of ferrous sulfate daily and 600 mg of ferrous sulfate weekly.
Weekly supplementation of iron is far better in controlling iron deficiency anemia due to cost effectiveness and better compliance.
比较5至10岁儿童和育龄妇女(15至45岁)每日口服以及每周一次单剂量和双剂量硫酸亚铁补充剂后血红蛋白、平均红细胞体积、平均红细胞血红蛋白和铁蛋白水平的改善情况。
20名儿童每日接受200毫克硫酸亚铁,20名儿童每周接受一次相同剂量,持续两个月。10名妇女每日接受300毫克硫酸亚铁,10名妇女每周接受一次相同剂量,10名妇女每周接受一次600毫克硫酸亚铁,持续一个月。
每日和每周接受200毫克硫酸亚铁的儿童所有参数均显著改善。同样,每日接受300毫克硫酸亚铁和每周接受600毫克硫酸亚铁的妇女参数也显著改善。
由于成本效益和更好的依从性,每周补充铁剂在控制缺铁性贫血方面效果要好得多。