Johnson Michael D, Oberst Michael D, Lin Chen-Yong, Dickson Robert B
Department of Oncology, Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA.
Expert Rev Mol Diagn. 2003 May;3(3):331-8. doi: 10.1586/14737159.3.3.331.
There are increasing data that suggest a role for the serine protease matriptase and its inhibitor, hepatocyte growth factor activator inhibitor-1, in the pathogenesis and progression of ovarian cancer. This review will discuss the matriptase/inhibitor system in the context of ovarian cancer and examine the possibility that this system might be a useful therapeutic and/or diagnostic target in this disease.
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