Suppression of chaos and other dynamical transitions induced by intercellular coupling in a model for cyclic AMP signaling in Dictyostelium cells.

The effect of intercellular coupling on the switching between periodic behavior and chaos is investigated in a model for cAMP oscillations in Dictyostelium cells. We first analyze the dynamic behavior of a homogeneous cell population which is governed by a three-variable differential system for which bifurcation diagrams are obtained as a function of two control parameters. We then consider the mixing of two populations behaving in a chaotic and periodic manner, respectively. Cells are coupled through the sharing of a common chemical intermediate, extracellular cAMP, which controls its production and release by the cells into the extracellular medium; the dynamics of the mixed suspension is governed by a five-variable differential system. When the two cell populations differ by the value of a single parameter which measures the activity of the enzyme that degrades extracellular cAMP, the bifurcation diagram established for the three-variable homogeneous population can be used to predict the dynamic behavior of the mixed suspension. The analysis shows that a small proportion of periodic cells can suppress chaos in the mixed suspension. Such a fragility of chaos originates from the relative smallness of the domain of aperiodic oscillations in parameter space. The bifurcation diagram is used to obtain the minimum fraction of periodic cells suppressing chaos. These results are related to the suppression of chaos by the small-amplitude periodic forcing of a strange attractor. Numerical simulations further show how the coupling of periodic cells with chaotic cells can produce chaos, bursting, simple periodic oscillations, or a stable steady state; the coupling between two populations at steady state can produce similar modes of dynamic behavior.