Bode J C, Wöltge E, Kahm O, Krob G
Dtsch Med Wochenschr. 1976 Jul 16;101(29):1081-7. doi: 10.1055/s-0028-1104218.
371 males admitted to a special hospital for withdrawal treatment of alcoholics were investigated on admission and repeatedly controlled during a follow-up of 3-6 months. In only 15% of all patients without delirium tremens there were no signs of liver disease on admission. 62% showed evidence of moderate or severe liver disease. 2-6 months after admission the percentage with moderate or severe liver disease had decreased (26%) while normal findings were obtained in 49%. On admission no correlation between frequency or degree of liver damage and the duration of alcohol abuse or daily intake of alcohol was demonstrated. Following abstinence of 2 months or more incidence of severe liver changes was nearly unchanged (16%) in patients drinking for more than 20 years, while it dropped distinctly in the groups with shorter duration of abuse (abuse less than 10 years: 5%). Histological alterations were distinctly more frequent in patients with abuse of more than 15 years (pronounced fibrosis 26%, cirrhosis 20%), as compared to alcoholics who drank less than 15 years (5 and 9%, respectively). In the patients with delirium tremens signs of severe liver disease were more frequent than in those without delirium. The trend towards normalisation of liver function tests was less in the former than in the latter (marked pathological findings following 2 months of alcohol abstinence in alcoholics with delirium tremens: duration of alcoholism less than 10 years: 16%; 11-20 years: 33%).
对371名入住戒酒专科医院进行戒酒治疗的男性患者在入院时进行了调查，并在3至6个月的随访期间进行了多次对照。在所有无震颤谵妄的患者中，只有15%在入院时没有肝病迹象。62%有中度或重度肝病的证据。入院后2至6个月，中度或重度肝病的比例有所下降（26%），而49%的患者肝功能检查结果正常。入院时，未发现肝损伤的频率或程度与酗酒持续时间或每日饮酒量之间存在相关性。戒酒2个月或更长时间后，饮酒超过20年的患者中严重肝脏病变的发生率几乎没有变化（16%），而在酗酒时间较短的组中（酗酒少于10年：5%）则明显下降。与酗酒少于15年的酗酒者（分别为5%和9%）相比，酗酒超过15年患者的组织学改变明显更为常见（明显纤维化26%，肝硬化20%）。在有震颤谵妄的患者中，严重肝病的迹象比无震颤谵妄的患者更为常见。前者肝功能检查结果恢复正常的趋势比后者小（有震颤谵妄的酗酒者戒酒2个月后有明显病理结果：酗酒时间少于10年：16%；11至20年：33%）。
