Dean Brian, Scarr Elizabeth, Pavey Geoffrey, Copolov David
The Rebecca L. Cooper Research Laboratories, The Mental Health Research Institute of Victoria, Parkville, Victoria, Australia.
J Affect Disord. 2003 Jun;75(1):65-9. doi: 10.1016/s0165-0327(02)00021-6.
Various studies suggest the hippocampus and serotonergic systems are important in the pathology of bipolar disorder (BD). We therefore measured hippocampal serotonergic markers in post-mortem tissue from BD and control subjects.
The density and affinity of [3H]citalopram binding to the serotonin transporter (SERT), as well as the density of the 5HT(2A), 5HT(1A), 5HT(1D) and 5HT(1F) receptors were measured.
The density of SERT and 5HT receptors was no different in BD. There was a significant decrease in the affinity of [3H]citalopram binding to SERT in the stratum lacunosum-moleculare (S(lac)) in BD (K(d) mean+/-S.E.M.=4.3+/-0.8 vs. 1.9+/-0.3 nM).
This study was completed using relatively small cohorts.
There are no generalised changes in hippocampal serotonergic markers in the hippocampus from subjects with BD. There is a decreased affinity of radioligand binding to S(lac) SERT in subjects with BD.
多项研究表明，海马体和血清素能系统在双相情感障碍（BD）的病理过程中起重要作用。因此，我们检测了BD患者和对照受试者尸检组织中的海马体血清素能标志物。
测量了[3H]西酞普兰与血清素转运体（SERT）结合的密度和亲和力，以及5HT（2A）、5HT（1A）、5HT（1D）和5HT（1F）受体的密度。
BD患者中SERT和5HT受体的密度没有差异。BD患者海马分子层（S（lac））中[3H]西酞普兰与SERT结合的亲和力显著降低（解离常数（K（d））平均值±标准误=4.3±0.8对1.9±0.3 nM）。
本研究使用的队列相对较小。
BD患者海马体中的血清素能标志物没有普遍变化。BD患者中放射性配体与S（lac）SERT结合的亲和力降低。
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