Vega Francisco M, Gonzalo Pilar, Gaspar María L, Lazo Pedro A
Instituto de Biología Molecular y Celular del Cáncer, Centro de Investigación del Cáncer, Consejo Superior de Investigaciones Científicas, Universidad de Salamanca, Spain.
FEBS Lett. 2003 Jun 5;544(1-3):176-80. doi: 10.1016/s0014-5793(03)00501-5.
The vaccinia-related kinase (VRK) proteins are a new group of three Ser-Thr kinases in the human kinome. VRK proteins are upstream regulators of several transcription factors. VRK1 phosphorylates p53 in Thr-18 within the region of binding to mdm2 preventing their interaction. The tissue distribution of three genes is still largely unknown. In the present report the expression of these genes was analyzed during murine hematopoietic development. The three genes are expressed in fetal liver and peripheral blood, with higher levels between days 11.5 and 13.5, a time when there is a massive expansion of liver cells, and thereafter their expression falls significantly. VRK genes are expressed, particularly at mid-gestation, in embryo thymus and spleen, but in adult thymus and spleen their levels are very low. VRK2 is expressed at lower levels than VRK1 and VRK3 in the mouse embryo. VRK genes play a role during embryonic development of hematopoiesis.
痘苗相关激酶（VRK）蛋白是人类激酶组中一组新的三种丝氨酸 - 苏氨酸激酶。VRK蛋白是几种转录因子的上游调节因子。VRK1在与mdm2结合的区域内的苏氨酸 - 18位点使p53磷酸化，阻止它们相互作用。这三个基因的组织分布在很大程度上仍然未知。在本报告中，分析了这些基因在小鼠造血发育过程中的表达情况。这三个基因在胎肝和外周血中表达，在第11.5天至13.5天之间表达水平较高，此时肝细胞大量扩增，此后其表达显著下降。VRK基因在胚胎胸腺和脾脏中表达，特别是在妊娠中期，但在成年胸腺和脾脏中其水平非常低。VRK2在小鼠胚胎中的表达水平低于VRK1和VRK3。VRK基因在造血的胚胎发育过程中发挥作用。
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