大鼠胃内碳酸氢钠灌注与迷走神经诱导的溃疡形成

Intragastric NaHCO3 perfusion and vagal-induced ulcer formation in the rat stomach.

作者信息

Ogle C W, Cho C H, Dai S

出版信息

Eur J Pharmacol. 1976 May;37(1):197-201. doi: 10.1016/0014-2999(76)90023-6.

Abstract

The effects of electrical vagal stimulation on gastric acid output and ulcer formation were studied in rats intragastrically perfused with saline or NaHCO3 solutions. Vagal stimulation produced a 100% incidence of glandular lesions and a significant increase in total acid output in saline-perfused stomachs. Antacid perfusion failed to prevent ulcer formation despite complete neutralization of the increased acid output. It is considered that vagal-induced gastric glandular lesions are not acid dependent.

摘要

在胃内灌注生理盐水或碳酸氢钠溶液的大鼠中，研究了电迷走神经刺激对胃酸分泌和溃疡形成的影响。迷走神经刺激使生理盐水灌注胃中腺体损伤的发生率达到100%，总酸分泌显著增加。尽管增加的酸分泌被完全中和，但抗酸剂灌注未能预防溃疡形成。据认为，迷走神经诱导的胃腺体损伤不依赖于酸。