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[甲状腺降钙素对心肌肾上腺素损伤恢复过程的影响]

[Effect of thyrocalcitonin on the recovery processes in adrenaline lesion of the myocardium].

作者信息

Sokolov I K, Belen'kiĭ E E, Tunitskaia T A, Kalugina G E, Briskin A I

出版信息

Farmakol Toksikol. 1976 Mar-Apr;39(2):167-73.

PMID:1278348
Abstract

Administration of thyrocalcitonine (TCT) in doses of 0.1 and 1 Un/kg for 14 days prevented the development of myocarditis in rats receiving epinephrine (3 mg/kg) for 4 days reduced the death rate among the animals, increased their body weight and normalized the electrolytes composition in the heart. Given in a dose of 10 Un/kg the drug produced a less pronounced positive effect on the study values in the animals with experimentally-produced epinephrine lesion of the heart. According to the authors this may be occasioned by an intensified secretion of the parathyroid hormone in response to a multiple introduction of large TCT doses to the animals.

摘要

以0.1和1单位/千克的剂量给予降钙素(TCT)14天,可预防接受肾上腺素(3毫克/千克)4天的大鼠发生心肌炎,降低动物死亡率,增加其体重,并使心脏中的电解质成分恢复正常。以10单位/千克的剂量给药,该药物对实验性肾上腺素性心脏损伤动物的研究指标产生的积极作用不那么明显。据作者称,这可能是由于对动物多次大剂量注射TCT后,甲状旁腺激素分泌增加所致。

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