Peddie Barbara A, Wood Jacqueline E, Lever Michael, Happer D Alan R, de Zwart Frederick, Chambers Stephen T
Department of Nephrology, Christchurch Hospital, Private Bag 4710, Christchurch, New Zealand.
Antonie Van Leeuwenhoek. 2003;83(2):175-81. doi: 10.1023/a:1023305326164.
A series of hydrophilic aromatic and semi-aromatic betaines related to trigonelline was synthesized and tested for antimicrobial activity. 4-Methylthiazolium betaine was the only one that showed significant antibacterial activity towards Escherichia coli under hyperosmotic conditions. None of the tested betaines showed any evidence of osmoprotection or urea protection.
合成了一系列与胡芦巴碱相关的亲水性芳香和半芳香甜菜碱，并测试了它们的抗菌活性。4-甲基噻唑鎓甜菜碱是唯一在高渗条件下对大肠杆菌表现出显著抗菌活性的化合物。所测试的甜菜碱均未显示出任何渗透保护或尿素保护的迹象。
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