Dawson D Y, Hudson S E, Mascharak P K
Department of Chemistry and Biochemistry, University of California, Santa Cruz 95064.
J Inorg Biochem. 1992 Aug;47(2):109-17. doi: 10.1016/0162-0134(92)84047-q.
Synthetic analogues of the iron-bleomycins, namely [Fe(PMA)]2+ and [Fe(PMA)]+, have been studied as oxotransfer agents. Oxygen transfer has been observed using iodosobenzene (PhIO), hydrogen peroxide, and dioxygen as oxygen sources. The primary substrates were cis- and trans-stilbene. The products were determined to be cis- and trans-stilbene oxide, benzaldehyde, and deoxybenzoin. These products were recovered in ratios similar to those reported for the iron-bleomycins, albeit in lower yields. Iron complexes of simpler analogues are inactive as oxotransfer agents. This study provides further support that PMAH is an accurate model of the metal binding region of bleomycin.
铁-博来霉素的合成类似物，即[Fe(PMA)]2+和[Fe(PMA)]+，已作为氧转移剂进行了研究。已使用亚碘酰苯（PhIO）、过氧化氢和双氧作为氧源观察到了氧转移。主要底物是顺式和反式二苯乙烯。产物被确定为顺式和反式氧化二苯乙烯、苯甲醛和脱氧安息香。这些产物的回收率与铁-博来霉素报道的回收率相似，尽管产率较低。更简单类似物的铁配合物作为氧转移剂没有活性。这项研究进一步支持了PMAH是博来霉素金属结合区域的准确模型。
