黑腹果蝇的抗菌防御。

Drosophila melanogaster antimicrobial defense.

作者信息

Hetru Charles, Troxler Laurent, Hoffmann Jules A

机构信息

Institut de Biologie Moléculaire et Cellulaire, UPR9022 du Centre National de la Recherche Scientifique, Strasbourg, France.

出版信息

J Infect Dis. 2003 Jun 15;187 Suppl 2:S327-34. doi: 10.1086/374758.

DOI:10.1086/374758

PMID:12792847

Abstract

The Drosophila melanogaster host defense is complex but remarkably efficient. It is a multifaceted response to a variety of fungal, bacterial, and parasitic invaders. Current knowledge is discussed on recognition of infectious microorganisms and on the activation of intracellular signaling cascades that concur with the expression of numerous immune-responsive genes, among which, to date, the most prominent appear to encode potent antimicrobial peptides.

摘要

果蝇的宿主防御机制复杂但极其高效。它是对各种真菌、细菌和寄生虫入侵者的多方面反应。本文讨论了目前关于识别感染性微生物以及激活细胞内信号级联反应的知识，这些反应与众多免疫反应基因的表达同时发生，其中，迄今为止，最突出的似乎是编码强效抗菌肽的基因。