Yu Zengli, Zhang Lishi, Wu Desheng
Huaxi School of Public Health, Sichuan University, Chengdu 610041, China.
Wei Sheng Yan Jiu. 2003 Mar;32(2):125-7.
Dietary genistein, a natural flavone compound found in soy, has been proposed to be related to the lower prevalence of breast cancer in Asian women. In order to elucidate the mechanism of chemopreventive effect of genistein so that to provide more scientific basis for dietary intervention for breast cancer in women, the apoptosis in estrogen responsive breast cancer cell lines (MCF-7 and T47D cells) was induced as the study model and the effect of genistein on the apoptosis was observed. The results showed that, functionally similar to the anti-estrogen tamoxifen, genistein induced in a dose- and time-dependent manner the MCF-7 cell apoptosis at concentrations above 20 x 10(-6) mol/L. The findings suggested that the increased isoflavone intake can induce apoptosis in estrogen responsive cells.
膳食染料木黄酮是一种存在于大豆中的天然黄酮类化合物，有人提出它与亚洲女性乳腺癌患病率较低有关。为了阐明染料木黄酮的化学预防作用机制，以便为女性乳腺癌的饮食干预提供更科学的依据，以雌激素反应性乳腺癌细胞系（MCF-7和T47D细胞）中的细胞凋亡为研究模型，观察了染料木黄酮对细胞凋亡的影响。结果表明，与抗雌激素他莫昔芬功能相似，染料木黄酮在浓度高于20×10（-6）mol/L时，以剂量和时间依赖性方式诱导MCF-7细胞凋亡。研究结果表明，增加异黄酮摄入量可诱导雌激素反应性细胞凋亡。
