Singh B N
Department of Cardiology, Wadsworth VA Hospital, Los Angeles, California 90073.
J Cardiovasc Pharmacol. 1992;20 Suppl 2:S75-90.
DL-Sotalol is a unique antiarrhythmic agent combining potent beta-blocking properties with the propensity to prolong cardiac repolarization in all myocardial tissues. Its beta-blocker-associated negative inotropic effects are attenuated by its action potential-lengthening effect. The drug has an elimination half-life of 10-15 h. Sotalol's major electrophysiologic profile constitutes the summed effects of beta-blockade and prolonged repolarization. It exerts a potent antifibrillatory action modulated by its antiadrenergic effects. The effectiveness and tolerance of sotalol in a variety of atrial and ventricular dysrhythmias is reviewed in the present article.
DL-索他洛尔是一种独特的抗心律失常药物，它兼具强效的β受体阻滞特性以及延长所有心肌组织心脏复极化的倾向。其与β受体阻滞剂相关的负性肌力作用因动作电位延长效应而减弱。该药物的消除半衰期为10 - 15小时。索他洛尔的主要电生理特征是β受体阻滞和复极化延长的综合效应。它通过抗肾上腺素能作用发挥强效的抗纤颤作用。本文综述了索他洛尔在各种房性和室性心律失常中的有效性和耐受性。
