Labanauskaite Grazina
Clinic of Radiology, Kaunas University of Medicine Hospital, Lithuania.
Medicina (Kaunas). 2003;39(5):484-8.
The purpose of this study was to investigate the intra-articular vascularization of the synovial pannus of patients with rheumatoid arthritis with power Doppler sonography and to correlate these findings with clinical findings and laboratory measures of disease activity. Seventy-four different joints of 23 patients with diagnosis of rheumatoid arthritis were studied. Clinical and functional assessment (number of swollen joints, visual analogue scale) and laboratory evaluation were made for all patients. Disease activity was evaluated using the disease activity score (DAS28) for each patient. The power Doppler sonography vascularity of the synovial membrane was classified semiquantatively. The strong correlation was found between qualitative power Doppler sonography results with joints with clinically active arthritis (Spearman's correlation coefficient was 0.67, p=0.0001). The power Doppler sonography was weakly correlated with disease activity score. No correlation was found with age, disease duration, and other laboratory and clinical variables. Power Doppler sonography may be a valuable tool to detect synovial vascularity and to assist clinicians in distinguishing between inflammatory and non-inflammatory pannus.
本研究的目的是采用能量多普勒超声检查法研究类风湿关节炎患者滑膜血管翳的关节内血管形成情况,并将这些结果与疾病活动的临床发现和实验室指标相关联。对23例诊断为类风湿关节炎的患者的74个不同关节进行了研究。对所有患者进行了临床和功能评估(肿胀关节数量、视觉模拟评分)以及实验室评估。使用疾病活动评分(DAS28)对每位患者的疾病活动度进行评估。对滑膜的能量多普勒超声血管情况进行半定量分类。发现能量多普勒超声定性结果与临床活动性关节炎关节之间存在强相关性(斯皮尔曼相关系数为0.67,p = 0.0001)。能量多普勒超声与疾病活动评分呈弱相关。未发现与年龄、病程以及其他实验室和临床变量存在相关性。能量多普勒超声检查法可能是检测滑膜血管形成情况以及协助临床医生区分炎性和非炎性血管翳的有价值工具。