环氧化酶-2在大肠腺瘤中的表达
Cyclooxygenase-2 expression in colorectal adenomas.
作者信息
Sato Takanobu, Yoshinaga Keigo, Okabe Satoshi, Okawa Takuya, Enomoto Masayuki, Takizawa Touichirou, Sugihara Kenichi
机构信息
Department of Digestive Surgery, Tokyo Medical and Dental University Graduate School, Japan.
出版信息
Dis Colon Rectum. 2003 Jun;46(6):786-92. doi: 10.1007/s10350-004-6658-2.
PURPOSE
Cyclooxygenase-2 is an important target for nonsteroidal anti-inflammatory drugs in suppressing colorectal tumorigenesis. To evaluate the role of cyclooxygenase-2 in sporadic colorectal adenoma, we correlated cyclooxygenase-2 expression in adenomas with other adenoma characteristics.
METHODS
Cyclooxygenase-2 expression was evaluated immunohistochemically in 95 endoscopically resected colorectal adenomas.
RESULTS
Cyclooxygenase-2 was expressed mainly in the cytoplasm of adenoma cells, where it was seen in 74 percent (70/95) of adenomas. Expression was related significantly to grade of dysplasia (P < 0.001) and tumor size (P = 0.028). Multivariate logistic regression analysis showed cyclooxygenase-2 expression in adenoma cells to be independently associated with grade of dysplasia (P = 0.001).
CONCLUSION
Observed associations suggest that cyclooxygenase-2 plays an important role in progression of the adenoma-to-carcinoma sequence.
目的
环氧化酶-2是非甾体抗炎药抑制结直肠癌发生的重要靶点。为评估环氧化酶-2在散发性结直肠腺瘤中的作用，我们将腺瘤中环氧化酶-2的表达与其他腺瘤特征进行了关联分析。
方法
采用免疫组织化学方法评估95例经内镜切除的结直肠腺瘤中环氧化酶-2的表达。
结果
环氧化酶-2主要在腺瘤细胞的细胞质中表达，95例腺瘤中有74%（70/95）可见其表达。表达与发育异常程度（P < 0.001）和肿瘤大小（P = 0.028）显著相关。多因素逻辑回归分析显示，腺瘤细胞中环氧化酶-2的表达与发育异常程度独立相关（P = 0.001）。
结论
观察到的关联表明，环氧化酶-2在腺瘤-癌序列进展中起重要作用。
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