Webber Philip R A, Cowley Andrew, Drew Michael G B, Beer Paul D
Department of Chemistry, Inorganic Chemistry Laboratory, University of Oxford, South Parks Road, Oxford OX1 3QR, UK.
Chemistry. 2003 Jun 6;9(11):2439-46. doi: 10.1002/chem.200204518.
A new class of ionophore consisting of two calix[4]arene units linked through the lower rim by two ethylene chains, in combination with propyl ether and phenolic functional groups, has been developed. These calix[4]semitube molecules exhibit remarkable selectivity and fast complexation kinetics for potassium over all Group 1 metal cations. Molecular modelling studies, using structural models derived from crystallographic data, suggest the potassium cation is complexed by a horizontal, side-on route and not through the calix[4]arene annulus. The length of the bridging alkylene chain between the respective calix[4]arenes of the semitube structure dictates the strength and selectivity of alkali metal cation binding.
已开发出一类新型离子载体，它由两个通过两条乙烯链在下缘相连的杯[4]芳烃单元与丙基醚和酚官能团组合而成。这些杯[4]半管分子对钾离子相对于所有第1族金属阳离子表现出显著的选择性和快速的络合动力学。使用从晶体学数据得出的结构模型进行的分子建模研究表明，钾阳离子是通过水平的侧向途径络合的，而不是通过杯[4]芳烃环。半管结构中各个杯[4]芳烃之间的桥连亚烷基链的长度决定了碱金属阳离子结合的强度和选择性。
