Bremer CelesteAnn T, Lastrapes Ashton, Alper Arnold B, Mudad Raja
Section of Hematology and Oncology, Tulane University, New Orleans, Louisiana, USA.
Am J Clin Oncol. 2003 Jun;26(3):262-4. doi: 10.1097/01.COC.0000020649.11411.2B.
Chronic myelogenous leukemia (CML), hepatitis C, and interferon alpha (IFNalpha) have all been associated with renal dysfunction. In this paper we present a patient with the diagnosis of nephrotic syndrome and a known history of hepatitis C who received IFNalpha therapy for newly diagnosed CML. The renal biopsy showed focal segmental glomerulosclerosis, which has only been previously reported in two cases of CML treated with IFNalpha. There have also been two cases of patients with hepatitis C associated with focal segmental glomerulosclerosis. Despite the underlying hepatitis C, this case represents renal abnormalities consistent with IFNalpha therapy for CML.
慢性粒细胞白血病（CML）、丙型肝炎和α干扰素（IFNα）均与肾功能不全有关。在本文中，我们报告了一名被诊断为肾病综合征且有丙型肝炎病史的患者，该患者因新诊断的CML接受了IFNα治疗。肾活检显示局灶节段性肾小球硬化，此前仅在两例接受IFNα治疗的CML患者中报道过。也有两例丙型肝炎患者伴有局灶节段性肾小球硬化。尽管存在潜在的丙型肝炎，但该病例显示出与CML的IFNα治疗一致的肾脏异常。
