Weinraub Z, Avrech O M, Golan A, Zabow P, Ron-El R, Bukovsky I, Caspi E
Department of Obstetrics and Gynecology, Assaf Harofe Medical Center, Zerifin and Tel Aviv University Sackler School of Medicine, Israel.
Ultrasound Obstet Gynecol. 1992 Mar 1;2(2):104-6. doi: 10.1046/j.1469-0705.1992.02020104.x.
The effect of genetic amniocentesis on flow velocity waveforms in the fetal aorta and the umbilical artery, and fetal heart rate and their correlation with uterine contractions was examined in 75 pregnant women who underwent this procedure. Forty-three were untreated and 32 were pretreated with indomethacin. Median maternal age was 36 years and median gestational age was 18 weeks. The resistance index of waveforms from the fetal aorta was stable at 0.8 throughout the approximately 20-h study period in both groups, but the systolic/diastolic ratio in the umbilical artery increased significantly after amniocentesis in the untreated group, and remained stable in the treated group. Fetal heart rate remained at about 150 beats/min throughout all measurements in both groups. These findings indicate that genetic amniocentesis causes an increase in downstream resistance in the umbilical artery which, however, remains within normal limits. This mild fetoplacental response to amniocentesis can be suppressed by the administration of a potent prostaglandin inhibitor like indomethacin.
对75例行基因羊膜腔穿刺术的孕妇，研究了该操作对胎儿主动脉和脐动脉血流速度波形、胎儿心率的影响，以及它们与子宫收缩的相关性。其中43例未治疗，32例在术前用吲哚美辛预处理。孕妇年龄中位数为36岁，孕周中位数为18周。两组在约20小时的研究期间，胎儿主动脉波形的阻力指数均稳定在0.8，但未治疗组羊膜腔穿刺术后脐动脉的收缩/舒张比显著增加，而治疗组保持稳定。两组所有测量过程中胎儿心率均维持在约150次/分钟。这些发现表明，基因羊膜腔穿刺术会导致脐动脉下游阻力增加，不过仍在正常范围内。像吲哚美辛这样的强效前列腺素抑制剂可抑制羊膜腔穿刺术引起的这种轻微的胎盘胎儿反应。
