Bañuls José, Betlloch Isabel, Botella Rafael, Jiménez Maria José, Blanes Mar, Pascual José Carlos, Belinchón Isabel, Silvestre Juan Francisco
Department of Dermatology, Hospital General de Alicante, Pintor Baeza S/N, 03010 Alicante, Spain.
Eur J Dermatol. 2003 May-Jun;13(3):308-10.
Interstitial granulomatous dermatitis (IGD) is a histopathological disorder characterised by an infiltration of the reticular dermis with a predominance of interstitial and palisadic histiocytes with a few areas of degenerating collagen bundles associated with a variable number of polynuclear neutrophils and eosinophils. There are several clinical conditions with a pattern of IGD. The linear form associated with arthritis was the first variety described. There is also a second form, which presents with plaques. This variety may be associated with arthritis, use of certain drugs or the presence of different systemic disorders. We report a case of IGD with plaques and arthritis. We discuss the differential clinical and histological diagnosis with other inflammatory skin lesions, which may be associated with joint disorders and collagen degeneration. We believe that it should be considered in patients presenting with arthritis and skin lesions.
间质性肉芽肿性皮炎(IGD)是一种组织病理学疾病,其特征是网状真皮层浸润,主要为间质和栅栏状组织细胞,伴有一些变性胶原束区域,伴有数量不等的多核中性粒细胞和嗜酸性粒细胞。有几种临床情况具有IGD的表现形式。与关节炎相关的线状形式是最早描述的类型。还有第二种形式,表现为斑块。这种类型可能与关节炎、某些药物的使用或不同的全身性疾病有关。我们报告一例伴有斑块和关节炎的IGD病例。我们讨论了与其他可能与关节疾病和胶原变性相关的炎症性皮肤病变的鉴别临床和组织学诊断。我们认为,对于出现关节炎和皮肤病变的患者应考虑该病。