Ali Z
Department of Clinical Medical Sciences, Faculty of Medical Sciences, University of the West Indies, St Augustine, Trinidad and Tobago, West Indies.
West Indian Med J. 2003 Mar;52(1):23-6.
This retrospective study was undertaken to determine the incidence of acute respiratory disorders (ARD) in newborns delivered at the Mount Hope Women's Hospital (MHWH) from January 1 to December 31, 1994. The study also examined the relationships between incidence rate of ARD and maternal and neonatal parameters. Hyaline membrane disease (HMD), transient tachypnoea of the newborn (TTN), meconium aspiration syndrome (MAS), persistent fetal circulation (PFC) and pulmonary infection (PI) were identified as ARDs among 5062 live newborns using standard diagnostic criteria. Overall, 174/5062 neonates were diagnosed with ARD to give an incidence of 3.4% (104 males and 70 females). The most common ARD was PI (39%) followed by HMD (29%). The incidence of ARD in preterm infants was 20.6% (100/486) and 1.1% (48/4363) in term neonates. Hyaline membrane disease occurred mainly in the preterm and low birthweight babies. Transient tachypnoea of the newborn and PI were found in all gestational age groups. Asphyxia was present in 10.9% (19/174) at five minutes of age. It was more common in babies who developed HMD and PFC. Forty-one per cent (71/174) of babies with ARD required assisted ventilation. There were 58/174 (33%) deaths. More than a half of those ventilated died (39/71 or 55%); 2/3 of those with airleaks and all those with intraventricular haemorrhage died. Mortality was significantly associated with asphyxia at both one and five minutes of age. There was significantly greater mortality among neonates with HMD as compared to the other ARDs.
本回顾性研究旨在确定1994年1月1日至12月31日在霍普山妇女医院(MHWH)出生的新生儿急性呼吸道疾病(ARD)的发病率。该研究还考察了ARD发病率与母体及新生儿参数之间的关系。采用标准诊断标准,在5062例活产新生儿中,将透明膜病(HMD)、新生儿短暂性呼吸急促(TTN)、胎粪吸入综合征(MAS)、持续性胎儿循环(PFC)和肺部感染(PI)确定为ARD。总体而言,174/5062例新生儿被诊断为ARD,发病率为3.4%(男104例,女70例)。最常见的ARD是PI(39%),其次是HMD(29%)。早产儿ARD发病率为20.6%(100/486),足月儿为1.1%(48/4363)。透明膜病主要发生在早产儿和低体重儿中。新生儿短暂性呼吸急促和PI在所有孕周组中均有发现。出生后5分钟时,10.9%(19/174)的新生儿存在窒息。在发生HMD和PFC的婴儿中更常见。41%(71/174)患ARD的婴儿需要辅助通气。有58/174(33%)例死亡。接受通气治疗的婴儿中有一半以上死亡(39/71或55%);发生气漏的婴儿中有2/3死亡,所有发生脑室内出血的婴儿均死亡。死亡率与出生后1分钟和5分钟时的窒息显著相关。与其他ARD相比,患HMD的新生儿死亡率显著更高。