α干扰素诱发一名格雷夫斯病患者出现短暂性严重甲状腺功能减退。
Interferon-alpha-induced transient severe hypothyroidism in a patient with Graves' disease.
作者信息
Braga-Basaria M, Basaria S
机构信息
*SEMPR, (Division of Endocrinology and Metabolism) Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, Brazil,
出版信息
J Endocrinol Invest. 2003 Mar;26(3):261-4. doi: 10.1007/BF03345167.
Interferons (IFNs) are proteins with anti-viral activity and are widely used in the treatment of patients with chronic hepatitis C virus (HCV) infection. The use of IFNs has resulted in thyroid dysfunction in a variety of ways. We report a case of a woman with hyperthyroidism due to Graves' disease who developed significant hypothyroidism during treatment with IFN-alpha 2a for HCV infection. However, after discontinuation of IFN-alpha 2a, hyperthyroidism recurred. Potential mechanisms by which IFNs influence thyroid function are discussed.
干扰素（IFNs）是具有抗病毒活性的蛋白质，广泛用于治疗慢性丙型肝炎病毒（HCV）感染患者。干扰素的使用已通过多种方式导致甲状腺功能障碍。我们报告一例因格雷夫斯病患有甲状腺功能亢进的女性，在使用α-2a干扰素治疗HCV感染期间出现明显的甲状腺功能减退。然而，停用α-2a干扰素后，甲状腺功能亢进复发。文中讨论了干扰素影响甲状腺功能的潜在机制。
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