1993 - 2000年意大利散发性克雅氏病（CJD）的死亡率趋势

Mortality trend from sporadic Creutzfeldt-Jakob disease (CJD) in Italy, 1993-2000.

作者信息

Puopolo Maria, Ladogana Anna, Almonti Susanna, Daude Nathalie, Bevivino Simona, Petraroli Rosella, Poleggi Anna, Quanguo Liu, Pocchiari Maurizio

机构信息

Laboratory of Pathophysiology, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.

出版信息

J Clin Epidemiol. 2003 May;56(5):494-9. doi: 10.1016/s0895-4356(02)00606-6.

DOI:10.1016/s0895-4356(02)00606-6

PMID:12812825

Abstract

The objective was to identify any possible cases of variant Creutzfeldt-Jakob disease (CJD) in Italy, and to estimate the trends in mortality from sporadic CJD for 1993-2000. CJD cases were ascertained through direct notification to the Registry; 382 definite or probable sporadic CJD patients, but no cases of variant CJD were identified. The average yearly mortality rate was 1.04 cases per million inhabitants, with an increase in deaths in the 60-69 and > or =70 year age groups. Survival was shorter in male respect to female and in patients with an age at onset > or =65 years. CJD cases were uneven distributed among different regions in the period 1993-1995, but not herein after. The rise in mortality from sporadic CJD in Italy likely reflects increased awareness and better diagnosis during the years. However, continuous notification and postmortem examination of all suspected cases are recommended for optimal surveillance.

摘要

目的是确定意大利境内任何可能的变异型克雅氏病（CJD）病例，并估算1993 - 2000年散发性CJD的死亡率趋势。CJD病例通过直接向登记处报告来确定；共确定了382例确诊或疑似散发性CJD患者，但未发现变异型CJD病例。平均年死亡率为每百万居民1.04例，60 - 69岁和≥70岁年龄组的死亡人数有所增加。男性患者的生存期短于女性患者，且发病年龄≥65岁的患者生存期更短。1993 - 1995年期间，CJD病例在不同地区分布不均，但之后并非如此。意大利散发性CJD死亡率的上升可能反映出这些年人们的认识提高和诊断更加完善。然而，为了进行最佳监测，建议持续报告并对所有疑似病例进行尸检。