糖尿病大鼠肝脏中胰岛素样生长因子结合蛋白-2 mRNA的转录后调控
Post-transcriptional regulation of insulin-like growth factor binding protein-2 mRNA in diabetic rat liver.
作者信息
Ooi G T, Tseng L Y, Rechler M M
机构信息
Growth and Development Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892.
出版信息
Biochem Biophys Res Commun. 1992 Dec 15;189(2):1031-7. doi: 10.1016/0006-291x(92)92307-j.
IGFBP-1 and IGFBP-2 mRNAs are increased in the livers of streptozotocin-diabetic rats. A corresponding increase is observed in transcription of the IGFBP-1 but not the IGFBP-2 gene, indicating that the increase in steady-state levels of IGFBP-2 mRNA is a post-transcriptional effect. IGFBP-1 and IGFBP-2 mRNAs also differ in the rapidity of their response to insulin treatment: hepatic IGFBP-1 mRNA is normalized within 1 h, IGFBP-2 mRNA decreases more slowly. These differences suggest that IGFBP-2 may provide more chronic adaptation to metabolic change than IGFBP-1.
在链脲佐菌素诱导的糖尿病大鼠肝脏中，胰岛素样生长因子结合蛋白1（IGFBP-1）和胰岛素样生长因子结合蛋白2（IGFBP-2）的信使核糖核酸（mRNAs）水平升高。IGFBP-1基因的转录有相应增加，但IGFBP-2基因没有，这表明IGFBP-2 mRNA稳态水平的升高是转录后效应。IGFBP-1和IGFBP-2 mRNAs对胰岛素治疗的反应速度也有所不同：肝脏中的IGFBP-1 mRNA在1小时内恢复正常，而IGFBP-2 mRNA下降得更慢。这些差异表明，与IGFBP-1相比，IGFBP-2可能为代谢变化提供更持久的适应性。
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