Pletz M W, Petzold P, Allen A, Burkhardt O, Lode H
Department of Chest and Infectious Diseases, City Hospital E v Behring, Free University of Berlin, Germany.
Antimicrob Agents Chemother. 2003 Jul;47(7):2158-60. doi: 10.1128/AAC.47.7.2158-2160.2003.
We investigated the effect of calcium carbonate on the oral bioavailability of gemifloxacin. Gemifloxacin was administered alone, 2 h before, simultaneously, or 2 h after calcium carbonate in 16 volunteers. Data for 320 mg of gemifloxacin alone were as follows: maximum concentration of drug in serum (C(max)),13 microg/ml; half-life, 7.33 h; and area under the concentration-time curve from 0 h to infinity (AUC( infinity )), 6.79 microg. h/ml. Only simultaneous coadministration of calcium carbonate reduced C(max) (-17%) and AUC( infinity ) (-21%) significantly.
我们研究了碳酸钙对吉米沙星口服生物利用度的影响。在16名志愿者中,分别单独给予吉米沙星,或在给予碳酸钙前2小时、同时或给予碳酸钙后2小时给予吉米沙星。单独给予320毫克吉米沙星的数据如下:血清中药物的最大浓度(C(max))为13微克/毫升;半衰期为7.33小时;从0小时到无穷大的浓度-时间曲线下面积(AUC( infinity ))为6.79微克·小时/毫升。只有同时给予碳酸钙会显著降低C(max)(-17%)和AUC( infinity )(-21%)。