Berg Andreas, Singer Thomas, Moser Ewald
Department of Medical Physics, University of Vienna, Woehringerstr, 13, A-1090 Vienna, Austria.
Invest Radiol. 2003 Jul;38(7):460-6. doi: 10.1097/01.rli.0000078762.72335.57.
To establish whether it is possible to quantitatively characterize the degenerative changes in cartilage that typify arthritis on a sub-150-microm resolution scale using a 3.0 T whole body MR-scanner with a reasonable measurement time.
This problem is addressed through diffusion-microimaging investigations on an arthritis model based on the enzymatic destruction of the proteoglycans in cartilage specimen. A 35-mm birdcage resonator made high spatial resolution possible, and diffusion-micro-imaging was achieved with the use of a strong gradient system.
Diffusion-weighted and quantitative parameter maps were acquired with 117 x 234 microm2 pixel resolution in less than 9 minutes. Diffusivity profiles and parameter images exhibit an increase in diffusivity in degenerated tissue.
In a trypsin-based arthritis model, the spatial localization and quantification of damaged areas have been shown to be possible on a whole body 3.0 T MR system. Measurement times achieved for these high spatial resolution studies make in vivo investigations feasible.
使用具有合理测量时间的3.0 T全身磁共振成像扫描仪，确定是否有可能在亚150微米分辨率尺度上对典型关节炎软骨的退行性变化进行定量表征。
通过对基于软骨标本中蛋白聚糖酶促破坏的关节炎模型进行扩散显微成像研究来解决这个问题。一个35毫米的鸟笼式谐振器使高空间分辨率成为可能，并使用强梯度系统实现了扩散显微成像。
在不到9分钟的时间内，以117×234微米²的像素分辨率获取了扩散加权和定量参数图。扩散率分布图和参数图像显示退化组织中的扩散率增加。
在基于胰蛋白酶的关节炎模型中，已证明在全身3.0 T磁共振系统上对受损区域进行空间定位和定量是可行的。这些高空间分辨率研究所实现的测量时间使体内研究成为可能。
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