De Pergola G, Pannacciulli N, Ciccone M, Tartagni M, Rizzon P, Giorgino R
Internal Medicine, Endocrinology, and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy.
Int J Obes Relat Metab Disord. 2003 Jul;27(7):803-7. doi: 10.1038/sj.ijo.0802292.
To evaluate the relation between free testosterone (FT) levels and the intima-media thickness of the common carotid artery (IMT-CCA) in overweight and obese glucose-tolerant (NGT) young adult men.
Cross-sectional study of FT and IMT-CCA in obese men.
A total of 127 overweight and obese NGT male individuals, aged 18-45 y.
FT plasma levels; IMT-CCA, as measured by high-resolution B-mode ultrasound imaging; central fat accumulation, as evaluated by waist circumference; body composition, as measured by bioimpedance analysis; insulin resistance, as calculated by homeostatic model assessment (HOMA(IR)); systolic and diastolic blood pressure; and fasting concentrations of glucose, insulin, and lipids.
IMT-CCA was positively correlated with age, body mass index (BMI), fat mass (FM), waist circumference, and fasting glucose concentrations, and inversely associated with FT levels. After multivariate analysis, IMT-CCA maintained an independent association with BMI, FM, and FT levels. This study indicates that IMT-CCA is negatively associated with FT levels, independent of age, total body fat, central fat accumulation, and fasting glucose concentrations in overweight and obese NGT patients.
Hypotestosteronemia may accelerate the development of atherosclerosis and increase the risk for CHD in obese men.
评估超重和肥胖糖耐量正常（NGT）年轻成年男性的游离睾酮（FT）水平与颈总动脉内膜中层厚度（IMT-CCA）之间的关系。
对肥胖男性的FT和IMT-CCA进行横断面研究。
共127名年龄在18至45岁之间的超重和肥胖NGT男性个体。
血浆FT水平；通过高分辨率B型超声成像测量的IMT-CCA；通过腰围评估的中心脂肪堆积；通过生物电阻抗分析测量的身体成分；通过稳态模型评估（HOMA(IR)）计算的胰岛素抵抗；收缩压和舒张压；以及空腹血糖、胰岛素和血脂浓度。
IMT-CCA与年龄、体重指数（BMI）、脂肪量（FM）、腰围和空腹血糖浓度呈正相关，与FT水平呈负相关。多变量分析后，IMT-CCA与BMI、FM和FT水平保持独立关联。本研究表明，在超重和肥胖的NGT患者中，IMT-CCA与FT水平呈负相关，不受年龄、全身脂肪、中心脂肪堆积和空腹血糖浓度的影响。
低睾酮血症可能会加速肥胖男性动脉粥样硬化的发展并增加冠心病风险。
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