病毒表位的构象特异性。
The conformational specificity of viral epitopes.
作者信息
Van Regenmortel M H
机构信息
Institut de Biologie Moléculaire et Cellulaire, CNRS, Strasbourg, France.
出版信息
FEMS Microbiol Lett. 1992 Dec 15;100(1-3):483-7. doi: 10.1111/j.1574-6968.1992.tb14081.x.
Abstract
Four types of antigenic sites found in viruses are discussed: cryptotopes, neotopes, metatopes and neutralization epitopes. The role played by conformation on the specificity of viral epitopes is illustrated in the case of tobacco mosaic virus and influenza virus. It appears that mechanisms reminiscent of induced fit contribute to the recognition of viral epitopes by antibodies.
摘要
文中讨论了在病毒中发现的四种抗原位点
隐蔽表位、新表位、变位表位和中和表位。以烟草花叶病毒和流感病毒为例，说明了构象对病毒表位特异性所起的作用。似乎类似于诱导契合的机制有助于抗体识别病毒表位。
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