[肿瘤学中的细胞周期与检查点：新的治疗靶点]
[Cell cycle and checkpoints in oncology: new therapeutic targets].
作者信息
Pommier Yves, Kohn Kurt W
机构信息
Laboratoire de pharmacologie moléculaire, Center for Cancer Research, National Cancer Institute, Bldg 37, Room 5068, NIH, Bethesda, MD 20892-4255, USA.
出版信息
Med Sci (Paris). 2003 Feb;19(2):173-86. doi: 10.1051/medsci/2003192173.
PMID:12836612
Abstract
Leland H. Hartwell, Paul M. Nurse et R. Timothy Hunt just received the Nobel price for their discovery of the molecular components of the cell cycle and cell cycle checkpoints. This review is an update of the molecular networks driving the cell cycle and its regulation, and of the importance of this knowledge for understanding the mechanisms driving oncogenesis and therapeutic developments.
摘要
利兰·H·哈特韦尔、保罗·M·纳斯和R·蒂莫西·亨特因发现细胞周期和细胞周期检查点的分子组成部分而刚刚获得诺贝尔奖。这篇综述是对驱动细胞周期及其调控的分子网络，以及这些知识对于理解肿瘤发生机制和治疗进展的重要性的更新。
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