Childhood antecedents of schizophrenia: developmental sequencing and specificity of problem behavior.

Childhood antecedents of schizophrenia were explored for 148 boys seen in child guidance clinics prior to the onset of adolescent or adult disorders. Those most disturbed in childhood were more likely to be preschizophrenic, and their disturbed behavior was relatively specific to that grouping. Childhood problems with motor coordination and attention were associated with impulsive, inappropriate behavior which led to peer rejection followed by increasing seclusiveness. Clinical grouping of the most disturbed boys produced composite descriptions for four groups.