[胺碘酮对兔体内普鲁卡因胺及其主要代谢产物处置动力学的影响]
[Effects of amiodarone on kinetics of procainamide and its major metabolite disposition in rabbit].
作者信息
Liu X Q, Huang S K
机构信息
Department of Pharmacology, China Pharmaceutical University, Nanjing.
出版信息
Zhongguo Yao Li Xue Bao. 1992 Sep;13(5):454-6.
The effects of steady state amiodarone on the kinetics of procainamide (PA) and its major metabolite, acetylprocainamide (NAPA), disposition in rabbits were examined. When PA was given alone, the pharmacokinetic parameters alpha, beta, Kmo, K1m.V1.V-1m, were 0.20 +/- 0.04, 0.016 +/- 0.003, 0.027 +/- 0.01, and 0.043 +/- 0.02 min-1, respectively. When PA was given in combination with amiodarone, the corresponding values were 0.37 +/- 0.08, 0.0059 +/- 0.002, 0.0096 +/- 0.004, and 0.016 +/- 0.003 min-1, respectively. The results indicated that the disposition kinetics of both PA and NAPA were significantly changed by steady state amiodarone.
研究了稳态胺碘酮对普鲁卡因胺（PA）及其主要代谢产物N - 乙酰普鲁卡因胺（NAPA）在兔体内处置动力学的影响。单独给予PA时，药代动力学参数α、β、Kmo、K1m、V1、V - 1m分别为0.20±0.04、0.016±0.003、0.027±0.01和0.043±0.02 min⁻¹。当PA与胺碘酮联合给药时，相应的值分别为0.37±0.08、0.0059±0.002、0.0096±0.004和0.016±0.003 min⁻¹。结果表明，稳态胺碘酮显著改变了PA和NAPA的处置动力学。
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