Uenishi Takahiro, Hirohashi Kazuhiro, Kubo Shoji, Yamamoto Takatsugu, Yamazaki Osamu, Shuto Taichi, Tanaka Hiromu, Kinoshita Hiroaki
Department of Gastroenterological and Hepato-biliary-pancreatic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
Hepatogastroenterology. 2003 Jul-Aug;50(52):1069-72.
BACKGROUND/AIMS: As the overall prognosis for patients with intrahepatic cholangiocarcinoma is extremely poor, it is important to identify specific clinicopathologic features associated with long-term survival after hepatic resection for this tumor.
Of 54 patients who underwent hepatic resection for intrahepatic cholangiocarcinoma, 9 survived more than 5 years after surgery (survival group), while 28 patients died of recurrence within 3 years of surgery (early recurrence group). Clinicopathologic features were compared retrospectively between groups.
Although clinical features in patients with long-term survival were similar to those in patients with early recurrence, lymphatic invasion, lymph node metastasis, intrahepatic metastasis and tumor involving the resection margin were more frequent in patients with early recurrence.
Hepatic resection for intrahepatic cholangiocarcinoma without lymph node metastasis or intrahepatic metastasis offers hope for long-term survival.
背景/目的：由于肝内胆管癌患者的总体预后极差，因此确定与该肿瘤肝切除术后长期生存相关的特定临床病理特征非常重要。
在54例行肝切除术治疗肝内胆管癌的患者中，9例术后存活超过5年（生存组），而28例患者在术后3年内死于复发（早期复发组）。对两组的临床病理特征进行回顾性比较。
尽管长期存活患者的临床特征与早期复发患者相似，但早期复发患者的淋巴管侵犯、淋巴结转移、肝内转移和肿瘤累及手术切缘更为常见。
对于无淋巴结转移或肝内转移的肝内胆管癌患者，肝切除术为长期生存带来了希望。
