Wikberg J E S, Mutulis F, Mutule I, Veiksina S, Lapinsh M, Petrovska R, Prusis P
Department of Pharmaceutical Biosciences, Uppsala University, Box 591, SE-751 24 Uppsala, Sweden.
Ann N Y Acad Sci. 2003 Jun;994:21-6. doi: 10.1111/j.1749-6632.2003.tb03158.x.
The melanocortin receptors exist in five subtypes, MC(1-5)R. These receptors participate in important regulations of the immune system, central behavior, and endocrine and exocrine glands. Here we provide a short review on MCR subtype selective peptides and organic compounds with activity on the MCRs, developed in our laboratory. Also provided is an overview of our new proteochemometric modeling technology, which has been applied to model the interaction of MSH peptides with the MCRs.
黑皮质素受体存在五种亚型，即MC(1 - 5)R。这些受体参与免疫系统、中枢行为以及内分泌和外分泌腺的重要调节。在此，我们简要综述了我们实验室开发的对MCR亚型具有选择性的肽类以及对MCRs有活性的有机化合物。还概述了我们新的蛋白质化学计量学建模技术，该技术已用于模拟促黑素细胞激素肽与MCRs的相互作用。
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