Ostertag P, Kramer M F
Klinik und Poliklinik für Hals-, Nasen- und Ohrenkranke der Ludwig-Maximilians-Universität München, Munich.
Laryngorhinootologie. 2003 Jun;82(6):440-58; quiz 459-2. doi: 10.1055/s-2003-40533.
Epidemiological and clinical data are discussed dealing with a possible influence of inflammatory changes of the nasal and especially the paranasal tissue on lower airway disease like asthma, the so-called "sinobronchial syndrome". Even though there is clear evidence of an association of the upper with the lower airway diseases, a causal relationship and a possible work of action are still up for discussion. The literature has been reviewed, and different theories are discussed. Generally speaking, a branch of differently accentuated mechanisms seems to play a role.
本文讨论了流行病学和临床数据,涉及鼻腔尤其是鼻旁组织的炎症变化对哮喘等下呼吸道疾病(即所谓的“鼻支气管综合征”)可能产生的影响。尽管上呼吸道疾病与下呼吸道疾病之间存在明确的关联证据,但因果关系及可能的作用机制仍有待探讨。本文对相关文献进行了综述,并讨论了不同的理论。一般来说,一系列不同程度突出的机制似乎都在起作用。