Peddi Srinivas, Roth Bryan L, Glennon Richard A, Westkaemper Richard B
Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA.
Bioorg Med Chem Lett. 2003 Aug 4;13(15):2565-8. doi: 10.1016/s0960-894x(03)00504-3.
The synthesis and 5-HT(2A) receptor affinities of 2-substituted-5-aminomethyl-10,11-dihydrodibenzo[a,d]cycloheptene (AMDH) derivatives are described. Comparison of the effects of substitution on affinities allowed assignment of potential binding modes in comparison with DOB-like agonists/antagonists and 3-substituted 1-(aminomethyl)-9,10-dihydroanthracene structures.
描述了2-取代-5-氨基甲基-10,11-二氢二苯并[a,d]环庚烯(AMDH)衍生物的合成及其对5-HT(2A)受体的亲和力。通过比较取代基对亲和力的影响,与类似DOB的激动剂/拮抗剂和3-取代-1-(氨基甲基)-9,10-二氢蒽结构相比,确定了潜在的结合模式。