骨关节炎：了解其病理生理学、遗传学及治疗方法。
Osteoarthritis: understanding the pathophysiology, genetics, and treatments.
作者信息
Sinkov Vladamir, Cymet Tyler
机构信息
Johns Hopkins School of Medicine Baltimore, Maryland, USA.
出版信息
J Natl Med Assoc. 2003 Jun;95(6):475-82.
Abstract
Risk factors for developing osteoarthritis include age, previous joint injury, obesity, and a genetic predisposition. An imbalance of joint functioning initiates the disease process, which is then worsened through biochemical changes in the collagen in the joint. Joint pain is the cardinal clinical presentation. Radiographic and lab testing do not correlate well with the disease; therefore, diagnosis is made by clinical findings. Treatment focuses on maintaining joint function through the use of directed activity, physical therapy, and medications.
摘要
患骨关节炎的风险因素包括年龄、既往关节损伤、肥胖和遗传易感性。关节功能失衡引发疾病进程，随后通过关节中胶原蛋白的生化变化而恶化。关节疼痛是主要的临床表现。影像学和实验室检查与该疾病的相关性不佳；因此，诊断依据临床症状。治疗重点是通过有针对性的活动、物理治疗和药物来维持关节功能。
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