Liu Zhi-liang, Xu Ru-xiang, Jiang Xiao-dan, Yin Zhen, Luo Cheng-yi, Du Mou-xuan, Zou Yu-xi
Institute of Neuroscience of PLA, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China.
Di Yi Jun Yi Da Xue Xue Bao. 2003 Jul;23(7):652-4.
To investigate the effect of activated kainate receptor on both the excitatory and inhibitory synaptic transmission in the neurons in the hippocampal CA1 region.
Blind whole-cell voltage-clamp recordings were performed on the CA1 pyramidal cells in adult rat hippocampal slices to examine and analyze the effect of bath-applied kainate (10 micromol/L) on CA1 afferent fiber-evoked excitatory postsynaptic currents (EPSCs) and inhibitory postsynaptic currents (IPSCs), respectively.
Activation of kainate receptor significantly depressed both IPSCs (P <0.01) and EPSCs (P <0.01) in neurons in the hippocampus CA1 region.
Activation of kainate receptors directly inhibit excitatory and inhibitory input in those neurons, which contributes to the development of epilepsy in the hippocampus by affecting the dynamic balance of the hippocampal neurons.
研究激活的海人酸受体对海马CA1区神经元兴奋性和抑制性突触传递的影响。
对成年大鼠海马脑片CA1锥体细胞进行盲法全细胞电压钳记录，分别检测和分析浴加海人酸（10微摩尔/升）对CA1传入纤维诱发的兴奋性突触后电流（EPSCs）和抑制性突触后电流（IPSCs）的影响。
海人酸受体激活可显著抑制海马CA1区神经元的IPSCs（P<0.01）和EPSCs（P<0.01）。
海人酸受体激活直接抑制这些神经元的兴奋性和抑制性输入，通过影响海马神经元的动态平衡，促进海马癫痫的发生。
