A prospective study of 110 Ethiopians with thyrotoxicosis.

One hundred and ten Ethiopian thyrotoxic patients were studied between February 1986 and January 1991 in a weekly endocrine clinic of Tikur Anbessa Teaching Hospital (TATH) in Addis Ababa, Ethiopia. This gives an incidence of 22 patients per year. There were 14 males and 96 females (M:F = 1:7). Fifty three patients (48.2%) had Graves' hyperthyroidism, 37 (33.7%) toxic multinodular goitre (TMNG), 14 (12.7%) toxic adenoma, 4 (3.6%) Jodbasedow phenomenon and 2 (1.8%) had thyroiditis. The mean age was 29.2 +/- 9.8 (+/- S.D.) years for Graves' cases, 49.0 +/- 10.9 years for TMNG cases and 46.4 +/- 15.9 years for toxic adenoma cases. The clinical presentation was similar to other reported series. The majority (88.7%) of Graves' patients were below 40 years while 75.7% of TMNG patients were over 40 years of age; this is in keeping with the observed younger age incidence of Graves' hyperthyroidism and older age incidence of TMNG. All patients responded to propylthiouracil therapy and no major side effect was recognized. Nine patients underwent sub-total thyroidectomy of whom one became hypothyroid a year later. One became toxic after a year, while 6 remained euthyroid 3 years after the surgery; the other patient did not return subsequently. The result of this study shows that thyrotoxicosis is not a rare condition in Ethiopia.