Sudarshi Sonali, Stümpfle Richard, Armstrong Margaret, Ellman Thomas, Parton Simon, Krishnan Prabha, Chiodini Peter L, Whitty Christopher J M
The Hospital for Tropical Diseases, London, UK.
Trop Med Int Health. 2003 Aug;8(8):728-32. doi: 10.1046/j.1365-3156.2003.01069.x.
To assess whether the clinical and laboratory methods for diagnosing Strongyloides stercoralis infection in non-endemic countries is different between those who are chronically exposed and those who travel.
Analysis of laboratory and clinical data from 204 patients having S. stercoralis infection at the Hospital for Tropical Diseases, London.
Sixty-four travellers and 128 immigrants from endemic countries had laboratory-proven strongyloides. In those with microscopically proven disease, serology was 73% sensitive in travellers and 98% sensitive in immigrants (P < 0.001). There was no difference in the eosinophil count between the two groups with 19% having a normal count. Patterns of symptoms varied between the groups, and around one-third were asymptomatic in both groups. Serology was of limited use in follow-up.
Eosinophil count and stool microscopy are insufficiently sensitive to be used alone for screening strongyloides. The sensitivity of serology is good in immigrants with chronic infection, but lower in travellers.
评估在非流行国家，长期暴露人群与旅行者中，用于诊断粪类圆线虫感染的临床和实验室方法是否存在差异。
对伦敦热带病医院204例粪类圆线虫感染患者的实验室和临床数据进行分析。
64名旅行者和128名来自流行国家的移民经实验室证实感染粪类圆线虫。在显微镜检查确诊的患者中，血清学检测在旅行者中的敏感性为73%，在移民中的敏感性为98%（P<0.001）。两组嗜酸性粒细胞计数无差异，19%的患者计数正常。两组症状模式不同，两组中约三分之一的患者无症状。血清学检测在随访中的作用有限。
嗜酸性粒细胞计数和粪便显微镜检查单独用于筛查粪类圆线虫的敏感性不足。血清学检测在慢性感染移民中的敏感性良好，但在旅行者中较低。
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