重症肌无力患者鼻肌和小鱼际肌的递减反应

Decremental response of the nasalis and hypothenar muscles in myasthenia gravis.

作者信息

Niks Erik H, Badrising Umesh A, Verschuuren Jan J, Van Dijk J Gert

机构信息

Department of Neurology and Clinical Neurophysiology, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands.

出版信息

Muscle Nerve. 2003 Aug;28(2):236-8. doi: 10.1002/mus.10411.

DOI:10.1002/mus.10411

PMID:12872330

Abstract

Repetitive nerve stimulation (RNS) is a standard diagnostic procedure in myasthenia gravis (MG). Although RNS sensitivity is highest in weak muscles, RNS is easier to perform in distal muscles that are often not affected. Twenty-five patients with MG were assessed to compare the sensitivity of RNS of the nasalis muscle to that of the hypothenar muscles. Abnormal decrement was found in hypothenar muscles in 9 patients (36%) and in the nasalis muscle in 13 patients (52%). RNS of the nasalis muscle appeared more useful to detect abnormal neuromuscular transmission in patients with oculobulbar MG (5 of 5) than hypothenar RNS (1 of 5). In patients with generalized MG, hypothenar muscles had a similar yield of abnormal RNS tests.

摘要

重复神经刺激（RNS）是重症肌无力（MG）的一项标准诊断程序。虽然RNS在无力肌肉中的敏感性最高，但RNS在通常未受影响的远端肌肉中更容易实施。对25例MG患者进行评估，以比较鼻肌与小鱼际肌RNS的敏感性。9例患者（36%）的小鱼际肌出现异常递减，13例患者（52%）的鼻肌出现异常递减。对于检测球部型MG患者（5例中的5例）的异常神经肌肉传递，鼻肌RNS似乎比小鱼际肌RNS更有用（5例中的1例）。在全身型MG患者中，小鱼际肌异常RNS检测的阳性率相似。